Severe neonatal transimmune thrombocytopenia. Case report

Abstract

Neonatal immune thrombocytopenia affects newborns from the mothers suffering from autoimmune diseases such as: immune thrombocytopenia (ITP), systemic lupus erythematosus, hyperthyroidism or lymphop-roliferative disorders. Pathogenesis of the disease relay on the transplacental passage of maternal antiplatelet IgG. They destroy fetal/neonatal platelets and can cause a passive disease in a healthy newborn. On the basis of the international medical literature, the risk of thrombocytopenia in neonates born from mothers with ITP can reach up 75%. Nevertheless, the relation between the severity of maternal ITP and the disease in the newborn period was not revealed. The article presents the clinical observation of the term neonate with severe thrombocytopenia due to maternal ITP. The diagnosis built on the basis of the results of a comprehensive clinical and laboratory study of mother and neonate.

Keywords:neonatal thrombocytopenia, immune thrombocytopenic purpura, pregnancy, neonatal haematology, clinical observation

For citation: Nikitina I.V., Lenyushkina A.A., Balashova E.N., Krog-Yensen O.A., Morozov L.A., Svirin P.V., Vinogradova M.A., Ageen-kova E.V., Lavrentieva I.N., Zubkov V.V., Degtyarev D.N. Severe neonatal transimmune thrombocytopenia. Case report. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2019; 7 (4): 45-52. doi: 10.24411/2308-2402-2019-14005 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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