Cerebral oximetry as method of diagnostics of perinatal brain pathology in newborns with intrauterine growth retardation

• Inna I. Evsyukova
• Olga V. Kovalchuk-Kovalevskaya
• Natalia A. Zvereva
• Natalia G. Gurieva
• Tatiana A. Velichko

Abstract

The noninvasive monitoring by near-infrared spectroscopy (NIRS) is the perspective method for early diagnostics of the perinatal brain disorders.

Aim. We have studied cerebral oximetry values during the sleep-wake cycle in full-term newborns with intrauterine growth retardation (IUGR).

Material and methods. 15 newborns with IUGR were included in the research group, and 38 newborns in the control group. Cerebral oximetry (CrS02) was measured by NIRS (Somanetic INVOS 5100C, USA) from the left frontoparietal region and was recorded simultaneously by the polysomnography. The fraction of the tissue oxygen extraction (FTOE) was calculated by using SaO2 (pulse oximeter Radical “Masimo”) and CrS02. It was analyzed for 15 minutes by polysomnography-defined: quiet, active sleep, and wake.

Results and discussion. Cerebral oxygen saturation in newborns with IUGR were significantly higher during sleep and wake. Nevertheless, FTOE was considerably lower in the research group than in the control group. The number of erythrocytes with an optimal activity in the research group was 42.8±2.3% versus 60.1±1.2% in control newborns (p<0.05). The low oxygen consumption during the active phase of the first cycle of the sleeping (REM) sleep and wake is indicators of the perinatal defeat of brain functional development.

Conclusion. The usage of NIRS will be a new method for the diagnostic and prognosis of the perinatal pathology of the brain.

Keywords:newborns, intrauterine growth retardation, cerebral oximetry, sleep, wake

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