Dynamics of prostacycline concentration in urine of patent ductus arteriosus in preterm infants

Abstract

The aim of our research is an analysis of the concentration of prostacyclin in the urine of preterm infants. Our goal was the identification of additional criteria for diagnosing the patent ductus arteriosus (PDA).

Material and methods. Eighty-two preterm infants with extremely low and very low birth weight delivered before 32 weeks of gestation were examined. Newborns were divided into two groups depending on the presence of PDA. The research group consisted of 22 newborns with PDA. Sixty newborns without PDA were included in the control group. Newborns in both groups underwent a cardiac ultrasound on 2-3 days of life. The level of prostacyclin in the urine on 4-5 days and 28 days was examined. Prostacyclin in the urine was determined by enzyme-linked immunosorbent assay (ELISA).

Results and discussion. The concentration of prostacyclin in the urine of children in the research group for 4-5 days was significantly higher than in newborns in the control group (1335.1 vs 1201.35 pg/ ml; p=0.02). The PDA has diagnosed with a rate of 73.5% with the prostacyclin's concentration in the urine of more than 1278.4 pg/ml at the same age. On 28 days of life, babies from the control group revealed a significant decrease in the concentration of prostacyclin in the urine compared with newborns in the research group (484,9 vs 1201,35 pg/ml, respectively; p=0.003).

Conclusion. The level of prostacyclin and dynamics of it in the first month of life are good predictors of the PDA in preterm newborns delivered before 32 weeks of gestation.

Keywords:preterm infants, prostacyclin, patent ductus arteriosus

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Fisuk Yu.A., Kharlamova N.V., Chasha T.V., Popova I.G., Sitnikova O.G., Nazarov S.B. Dynamics of prostacycline concentration in urine of patent ductus arteriosus in preterm infants. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2020; 8 (1): 16-21. doi: 10.33029/2308-2402-2020-8-1-16-21 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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