Assessment of the health of children born with the help of assisted reproductive technologies, according to the data of regional information medical systems

Abstract

The aim of the study is to assess the health of children conceived using assisted reproductive technologies (ART).

Material and methods. Children of the main (n=896, conceived using ART) and control groups (n=896 children, conceived naturally), aged 1-3 months, 6 months, 1 year, 1 year 6 months, 2 years, 2 years 6 months, 3 years. Methods: descriptive statistics, nonparametric Z-criterion for the share, with a reliable significance level of p-value <0.05.

Results. Children of the main group, versus with children of the control group, have unspecified encephalopathy (p=0.0396), neonatal jaundice associated with premature delivery (p=0.0180), gastroesophageal reflux without esophagitis (p=0.0002), comparing of the ICD-10 rubrics.

Conclusion. Children who was born using ART need a multidisciplinary approach in early care, development of individual rehabilitation and habilitation programs, and implementation of nutritional rehabilitation interventions.

Keywords:assisted reproductive technologies, children's health, early care, information and analytical systems

Funding. The study was carried out with the financial support of the Russian Foundation for Basic Research within the framework of the scientific project No. 19-37-90121.

Conflict of interests. The authors declare no conflict of interests.

For citation: Plaksina A.N., Kovtun O.P., Aver'yanov O.Yu., Kozhevnikova O.V., Sinotova S.L., Limanovskaya O.V., Makutina V.A. Assessment of the health of children born with the help of assisted reproductive technologies, according to the data of regional information medical systems. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2020; 8 (3): 18-25. DOI: https://doi.org/10.33029/2308-2402-2020-8-3-18-25 (in Russian)

References

1. Edict of the President of the Russian Federation of May 29, 2017 No. 240 "On the Declaration in the Russian Federation of the Decade of childhood".

2. Meister T., Rimoldi S., Soria R., von Arx R., et al. Association of assisted reproductive technologies with arterial hypertension during adolescence. J Am Coll Cardiol. 2018; 72 (11): 1267 - 74. DOI: https://doi.org/10.1016/j.jacc.2018.06.060

3. Norrman E., Petzold M., Bergh C., Wennerholm U.-B. School performance in children born after ICSI. Hum Reprod. 2020; 35 (2): 340-54. DOI: https://doi.org/10.1093/humrep/dez281

4. Zandstra H., Smits L.J.M., van Kuijk S.M.J., et al. No effect of IVF culture medium on cognitive development of 9-year-old children. Hum Reprod Open. 2018; 2018 (4): hoy018. DOI: https://doi.org/10.1093/hropen/hoy018

5. Spector L., Brown M., Wantman E., et al. Association of in vitro fertilization with childhood cancer in the United States. JAMA Pediatr. 2019; 173 (6): e190392. DOI: https://doi.org/10.1001/jamapediatrics.2019.0392

6. Zandstra H., Brentjens L.B., Spauwen B., et al Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years. Hum Reprod. 2018; 33 (9): 1645-56. DOI: https://doi.org/10.1093/humrep/dey246

7. Evert L.S., Galonsky V.G., Tepper E.A., et al. Pregnancy outcomes and health of children born following assisted reproductive technologies. Sibirskij medicinskij zhurnal [Siberian Scientific Medical Journal]. 2013; 28 (1): 65-9. (in Russian)

8. Kiseleva M.A., Buslaeva G.N., Karachunskaya E.M., Zholkovskaya M.V. Health and development of term children born after ivf at the age of 1-3 years. Zhurnal im. G.N. Speranskogo [Pediatria. Journal named after G.N. Speransky]. 2016; 95 (2): 196-7. (in Russian)

9. Keshishyan E.S., Caregorodcev A.D., Ziborova M.I. The health status of children born after in vitro fertilization. Rossiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2014; 59 (5): 15-25. (in Russian)

10. Zyuzikova Z.S., Volevodz N.N., Grigoryan O.R., et al. Health status of children conceived by assisted reproductive technologies: endocrinologist’s position. Problemy endokrinologii [Problems of Endocrinology]. 2018; 64 (4): 235-43. DOI: https://doi.org/10.14341/probl9470 (in Russian)

11. National ART Surveillance. https://www.cdc.gov/art/nass/index.html (date of access: 16.06.2019)

12. Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE. Hum Reprod. 2017; 32 (10): 1957-73. DOI: https://doi.org/10.1093/humrep/dex264

13. Sunderam S., Kissin D., Crawford S.B., et al. Assisted reproductive technology surveillance - United States, 2014. Surveillance Summaries. MMWR Surveill Summ. 2017; 66 (6): 1-24.

14. Kvashnina E.V., Askerov R.A., Majasina E.N. Take-home baby rate as a criteria of ivf quality. the analysis of pregnant women. Problemy re-produktsii [Russian Journal of Human Reproduction]. 2012; (2): 68-71. (in Russian)

15. von Wolff M., Haaf T. In vitro fertilization technology and child health risks, mechanisms and possible consequences. Dtsch Arztebl Int. 2020; 117 (3): 23-30. DOI: https://doi.org/10.3238/arztebl.2020.0023

16. Sullivan-Pyke C., Senapati S., Mainigi M., Barnhart K. In vitro fertilization and adverse obstetric and perinatal outcomes. Semin Perinatol. 2017; 41 (6): 345-53. DOI: https://doi.org/10.1053/j.semperi.2017.07.001

17. Fedder J., Loft A., Parner E.T., et al. Neonatal outcome and congenital malformations in children born after ICSI with testicular or epidid-ymal sperm: a controlled national cohort study. Hum Reprod. 2013; 28 (1): 230-40. DOI: https://doi.org/10.1093/humrep/des377

18. Shechter-Maor G., Czuzoj-Shulman N., Spence A., Abenhaim H. The effect of assisted reproductive technology on the incidence of birth defects among livebirths. Arch Gynecol Obstet. 2018; 297 (6): 1397-403. DOI: https://doi.org/10.1007/s00404-018-4694-8

19. Baranov A.A., Namazova-Baranova L.S., Belyaeva I.A., Bombard-irova E.P., Smirnov I.E. Medical and social problems of assisted reproductive technologies from the perspective of pediatrics. Vestnik Rossiiskoi aka-demii meditsinskikh nauk [Annals of the Russian Academy of Medical Sciences]. 2015; 70 (3): 307-14. DOI: https://doi.org/10.15690/vramn.v70i3.1326

20. Kovtun O.P., Plaksina A.N., Makutina V.A., Ankudinov N.O., Zil’ber N.A., Limanovskaja O.V., et al. Information-analytical assessment systems for perinatal outcomes and children’s health status born by assisted reproductive technologies. Rossiyskiy vestnik perinatologii i pe-diatrii [Russian Bulletin of Perinatology and Pediatrics]. 2020; 65: (1): 45-50. DOI: https://doi.org/10.21508/1027-4065-2020-65-1-45-50 (in Russian)

21. Declercq E., Luke B., Belanoff C., Cabral H., Diop H., Gopal D., et al. Perinatal outcomes associated with assisted reproductive technology: the Massachusetts Outcomes Study of Assisted Reproductive Technologies (MOSART). Fertil Steril. 2015; 103 (4): 888-95. DOI: https://doi.org/10.1016/j.fertnstert.2014.12.119

22. Qin J.B., Sheng X.Q., Wang H., Chen G.C., Yang J., Yu H., et al. Worldwide prevalence of adverse pregnancy outcomes associated with in vitro fertilization/intracytoplasmic sperm injection among multiple births: a systematic review and meta-analysis based on cohort studies. Arch Gynecol Obstet. 2017; 295 (3): 577-7. DOI: https://doi.org/10.1007/s00404-017-4291-2

23. Fruitless marriage. Versions and contraversions (monograph). Edited by V.E. Radzinsky Moscow: GEOTAR-Media; 2018: 404 p. ISBN 9785-9704-4602-7 (in Russian)

24. Plaksina A.N., Marchuk Yu.V., Dugina E.A. Nutrition taking into account the adjusted age / State Healthcare Institution Children’s Clinical Hospital for Rehabilitation Scientific and Practical Center "Bonum". Certificate of official registration of the computer program No. 2017662949 dated November 21, 2017. (in Russian)

25. Order of the Government of the Russian Federation of August 31, 2016 No. 1839-r "Concept for the development of early assistance in the Russian Federation for the period until 2020". http://static.government.ru/media/files/7NZ6EKa6SOcLcCCQbyMRXHsdcTmR9lki.pdf(data access: 26.03.2020) (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

Journals of «GEOTAR-Media»