Orofaringeal introduction of colostrine - survey data and theoretical prospects

Abstract

The aim of the study - to identify the frequency of practical use, the variety of methods for early oropharyngeal administration of colostrum (EOAC) among neonatologists and resuscitators in cities of the Russian Federation, the awareness of the importance of EOAC for newborn children and mothers.

Material and methods. A survey of 200 doctors was conducted on the developed monitoring map in 18 cities of the Russian Federation. The map is compiled by sections: city of residence, place of work, work experience in neonatology, application of the EOAC method with the response option «yes, no». If the answer is positive, the details of the technology were evaluated, namely the capacity used, the time of the first colostrum administration, the volume of colostrum injected, and the specific method.

Results. The frequency of using EOAC in premature and sick newborns in maternity ward among the doctors surveyed was 86%. A variety of methods have been identified. Most doctors express colostrum in a syringe, in a beaker, other vessels and inject directly into the newborn's oral cavity. Some doctors place colostrum on a cotton pad behind the cheek of a child or lubricate the baby's lips so, that the colostrum enters the oral cavity. The preferred method is expressing into a syringe. On average, a child receives up to 0.5 ml of colostrum.

Conclusions. The survey data indicate a high frequency of use of early oropharyngeal administration of colostrum to premature and sick newborns in cities of the Russian Federation. This reflects sufficient knowledge, understanding by doctors - neonatologists and resuscitators of the importance of administering colostrum to newborns, starting immediately after birth in the maternity ward when their condition is stabilized. The lack of a single optimal method requires the standardization of EOAC.

Keywords:neonatologists' and resuscitators' survey, colostrum, early oropharyngeal colostrum administration, premature and sick newborns

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Pavlova S.E., Sofronova L.N. Orofaringeal introduction of colostrine - survey data and theoretical prospects. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2020; 8 (3): 32-8. DOI: https://doi.org/10.33029/2308-2402-2020-8-3-32-38 (in Russian)

References

1. Snyder R., Herdt A., Mejias-Cepeda N., et al. Early provision of oropharyngeal colostrum leads to sustained breast milk feedings in preterm infants. Pediatr Neonatol. 2017; 58 (6): 534-40.

2. Seigel J.K., Smith P.B., Ashley P.L., et al. Early administration of oropharyngeal colostrum to extremely low birth weight infants. Breastfeed Med. 2013; 8 (6): 491-5.

3. The program for optimizing the feeding of children of the first year of life in the Russian Federation: guidelines; NRC Children’s Health of the Ministry of Health of Russia. Moscow; 2019: 112 p. (in Russian)

4. Belyaeva I.A., Namazova-Baranova L.S., Volodin N.N., et al. The organization of breastfeeding in the intensive care unit and intensive care of premature babies: discussion issues. Pediatricheskaya farmakologiya [Pediatric Pharmacology]. 2019; 16 (3): 152-8. (in Russian)

5. Cleminson J.S., Zalewski S.P., Embleton N.D. Nutrition in the preterm infant: what’s new? Curr Opin Clin Nutr Metab Care. 2016; 19 (3): 220-5.

6. Breastfeeding and use of human milk / American Academy of Pediatrics (AAP). Pediatrics. 2012; 129 (3): e827-41.

7. Garofalo N.A., Caplan M.S. Oropharyngeal mother’s milk: state of the science and influence on necrotizing Enterocolitis. Clin Perinatol. 2019; 46 (1): 77-88. DOI: https://doi.org/10.1016/j.clp.2018.09.005

8. Rodriguez N.A., Caplan M.S. Oropharyngeal administration of mother’s milk to prevent necrotizing enterocolitis in extremely low-birth-weight infants: theoretical perspectives. J Perinat Neonatal Nurs. 2015; 29 (1): 81-90. DOI: https://doi.org/10.1097/JPN.0000000000000087

9. Domingues-Bello M., Costello E.K., Contreras M., et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. PNAS. 2010; (107): 11971-5.

10. Netrebenko O.K., Shumilov P.V., Mukhina Yu.G. The new facets of nutrition: a guide for physicians. Moscow; 2018. (in Russian)

11. Sohn K., Kalanetra K.M., Mills D.A., et al. Buccal administration of human colostrum: impact on the oral microbiota of premature infants. J Perinatol. 2016; 36 (2): 106-11.

12. Ruiz L., Bacigalupe R., Garcia-Carral C., et al. Microbiota of human precolostrum and its potential role as a source of bacteria to the infant mouth. Sci Rep. 2019; 9 (1): 8435.

13. Ivanov D.O., Derevtsov V.V., Serova N.P Assessment of adaptation of infants born with different types mild intrauterine growth and development retardation. Pediatrician (St. Petersburg). 2019; 10 (3): 5-16. DOI: https://doi.org/10.17816/PED1035-16

14. Rodriguez N.A., Meier P.P., Groer M.W., et al. Oropharyngeal administration of colostrum to extremely low birth weight infants: theoretical perspectives. J Perinatol. 2009; 29 (1): 1-7. DOI: https://doi.org/10.1038/jp.2008.130

15. Haumont D., Tackoen M. The role of nutrition in the NIDCAP Concept. In: Recent advances in neonatal medicine. Wurzburg, 2014.

16. Neville M.C. Anatomy and physiology of lactation. Pediatr Clin North Am. 2001. 48 (1): 13-34. DOI: https://doi.org/10.1016/s0031-3955(05)70283-2

17. Ronayne de Ferrer P.A., Baroni A., Sambucetti M.E., et al. Lacto-ferrin levels in term and preterm milk. J Am Coll Nutr. 2000; (19): 370-3. DOI: https://doi.org/10.1080/07315724.2000.10718933

18. Buescher E.S. Anti-inflammatory characteristics of human milk: how, where and why. Adv Exp Med Biol. 2001; (501): 207-22.

19. Rodriguez N.A., Miracle D.J., Meier P.P. Sharing the science on human milk feedings with mothers of very low birth weight infants. J Obstet Gynecol Neonatal Nurs. 2005; (34): 109-19.

20. Araujo E.D., Goncalves A.K., Cornetta M., et al. Evaluation of the secretory immunoglobulin A levels in the colostrum and milk of mothers of term and preterm infants. Braz J Infect Dis. 2005; (9): 357-62.

21. Lee J., Kim H.S., Jung Y.H., et al. Oropharyngeal colostrum administration in extremely premature infants: an RCT. Pediatrics. 2015; (135): e357-66.

22. Haase B., Johnson T.S., Wagner C.L. Facilitating colostrum collection by hospitalized women in the early postpartum period for infant trophic feeding and oral immune therapy. J Obstet Gynecol Neonatal Nurs. 2018; 47 (5): 654-60.

23. Gephart S.M., Weller M. Colostrum as oral immune therapy to promote neonatal health. Adv Neonatal Care. 2014; 14 (1): 44-51.

24. Nasuf A.W.A., Ojha S., Dorling J. Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants. Cochrane Database Syst Rev. 2018; (9): CD011921. DOI: https://doi.org/10.1002/14651858.CD011921

25. Panchal H., Athalye-Jape G., Patole S. Oropharyngeal colostrum for preterm infants: a systematic review and meta-analysis. Adv Nutr. 2019; 10 (6): 1152-62. DOI: https://doi.org/10.1093/advances/nmz033

26. Romano-Keeler J., Azcarate-Peril M.A., Weitkamp J.H., et al. Oral colostrum priming shortens hospitalization without changing the immu-nomicrobial milieu. J Perinatol. 2017; 37 (1): 36-41. DOI: https://doi.org/10.1038/jp.2016.161

27. Tao J., Mao J., Yang J., et al. Effects of oropharyngeal administration of colostrum on the incidence of necrotizing enterocolitis, late-onset sepsis, and death in preterm infants: a meta-analysis of RCTs. Eur J Clin Nutr. 2020; 74: 1122-31. DOI: https://doi.org/10.1038/s41430-019-0552-4

28. Shamova K.P., Chistyakova G.N., Remizova I.I. Application of the technology of oropharyngeal colostrum for premature babies in the conditions of the Perinatal Center. Evraziyskiy Soyuz Uchenykh [Eurasian Union of Scientists]. 2018; 3 (48): 71-3. (in Russian)

29. Nancy A., Rodriguez R.N., Paula P., et al. A pilot study to determine the safety and feasibility of oropharyngeal administration of own mother’s colostrum to extremely low birth weight Infant. Adv Neonatal Care. 2010; 10 (4): 206-12.

30. Bocci V. Absorption of cytokines via oropharyngeal-associated lymphoid tissue. Does an unorthodox route improve the therapeutic index of interferon? Clin Pharmacokinet. 1991; 21 (6): 411-7. DOI: https://doi.org/10.2165/00003088-199121060-00002

31. Coppa G.V., Zampini L., Galeazzi T., et al. Human milk oligosaccharides inhibit the adhesion of caco-2 cells of diarrheal pathogens: escherichia coli, vibrio cholerae and salmonella fyris. Pediatr Res. 2006; 59 (3): 377-82.

32. Bashir T., Reddy K.V., Kiran S. Effect of colostrum given within the 12 hours after birth on feeding outcome, morbidity and mortality in very low birth weight infants: a prospective cohort study. Sudan J Paediatr. 2019; 19 (1): 19-24. DOI: https://doi.org/10.24911/SJP.106-1540825552

33. Moreno-Fernandez J., Sanchez-Martfnez B., Serrano-Lopez L., et al. Enhancement of immune response mediated by oropharyngeal colostrum administration in preterm neonates. Pediatr Allergy Immunol. 2019; 30 (2): 234-41. DOI: https://doi.org/10.1111/pai.13008

34. Martfn-Alvarez E., Diaz-Castro J., Pena-Caballero M., et al. Oropharyngeal colostrum positively modulates the inflammatory response in preterm neonates. Nutrients. 2020; 12 (2): E413. DOI: https://doi.org/10.3390/nu12020413

35. Gila-Diaz A., Arribas S.M., Algara A., et al. A review of bioactive factors in human breastmilk: a focus on prematurity. Nutrients. 2019; 11 (6): E1307. DOI: https://doi.org/10.3390/nu11061307

41. He Y., Liu S., Leone S., et al. Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine. Mucosal Immunol. 2014; 7 (6): 1326-39.

42. Kristensen-Cabrera A.I., Sherman J.P., Lee H.C. A prospective clinical study of PrimoLacto: A closed system for colostrum collection. PLoS ONE. 2018; 13 (11): e0206854. DOI: https://doi.org/10.1371/journal.pone.0206854

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

Journals of «GEOTAR-Media»