Homeostasis of minerals and trace elements in newborns. Part 2. Clinical role of magnesium balance in the body of newborn

Abstract

This review clarifies the distribution of magnesium in the body of newborns and infants, elucidates the main variants and clinical manifestations of magnesium imbalance in the newborn's body, describes the factors affecting magnesium homeostasis, particularly the metabolism and pharmacokinetics of magnesium, in newborns at different gestational ages; the methods of diagnosis, treatment and prevention of imbalances in magnesium homeostasis are considered. In the modern scientific literature information on this issue is scarce and often inconsistent. The review contains information available in open literature sources on the use of magnesium preparations and the clinical role of its different concentrations during pregnancy and childhood, methods of detection of magnesium imbalance, immediate and long-term consequences of hypo- and hypermagnesemia in infants. The practical importance of scientific data about the balance of magnesium in the newborn's body, methods of diagnosis and modes of treatment of the detected disorders are highlighted.

Keywords:newborn, magnesium, hypomagnesiemia, hypermagnesiemia, neuroprotection, tocolysis

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

Contribution. The contribution of the authors of the article was equal and consisted in collecting information, analyzing it and preparing the article for publication.

Acknowledgement. The authors are grateful to Daria S. Kryuchko, MD, PhD, DSc, for her assistance in preparing the material for publication.

For citation: Degtyareva M.V., Senkevich O.A., Karpova A.L., Karpov N.Yu. Homeostasis of minerals and trace elements in newborns. Part 2. Clinical role of magnesium balance in the body of newborn. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2020; 8 (1): 22-33. doi: 10.33029/2308-2402-2020-8-1-22-33 (in Russian)



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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425
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