Improvement of diagnostic measures in newborn babies born to mothers with syphilitic infection at the maternity hospital stage

Abstract

Aim of the study. To consider the possibility of creating a modern model of organization of medical care for children born to women with syphilitic infection detected during this pregnancy or within five years before its onset, with a differentiated approach and choice of diagnostic tactics at the maternity hospital stage.

Material and methods. The paper analyzes the data of a comprehensive examination of 397 newborns included in the studies indicating the fact of birth by a woman with a documented history of syphilitic infection, and who were under observation from birth to 1 month of life for the period 2003–2020.

Results. A comparison of the results of serological reactions confirms the diagnostic significance of a combination of non-treponemal (RMP) and treponemal (RPGA and IgM and IgG ELISA), but the highest diagnostic significance is noted with a combination of direct and indirect diagnostic methods, which determines the need to introduce new diagnostic models aimed at optimizing laboratory studies of children born to women with syphilis during a real pregnancy or for three years before a real pregnancy.

Discussion. The model of medical care involves the improvement of a set of measures by optimizing laboratory diagnostics at the maternity hospital stage.

Conclusion. The introduction of the proposed modern model of organization of medical care for children born to women with syphilitic infection will provide a new modern approach to the choice of diagnostic tactics at the perinatal center/maternity hospital stage.

Keywords:syphilis; newborn; congenital infection

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Research concept and design – Matyskina N.V., Taranushenko T.E.; collection and processing of the material, statistical data processing – Matyskina N.V.; writing a text – Matyskina N.V., Taranushenko T.E.; editing – Matyskina N.V., Taranushenko T.E., Vinnik Yu.Yu.

For citation: Matyskina N.V., Taranushenko T.E., Vinnik Yu.Yu. Improvement of diagnostic measures in newborn babies born to mothers with syphilitic infection at the maternity hospital stage. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2022; 10 (2): 14–20. DOI: https://doi.org/10.33029/2308-2402-2022-10-2-14-20 (in Russian)

REFERENCES

1. Potekaev N.N., Kupeeva I.A., Ivanova M.A., Frigo N.V., Dolya O.V., Zhukova O.V., et al. The incidence of sexually transmitted infections in the Russian Federation in 2014–2019. Klinicheskaya dermatologiya i venerologiya [Clinical Dermatology and Venerology]. 2021; 20 (1): 25–32. (in Russian).

2. Dmitriev G.A., Frigo N.V., Negasheva E.S., Rotanov S.V., Kitaeva N.V., Dolya O.V. Laboratory diagnostics of syphilis: modern priorities. Klinicheskaya dermatologiya i venerologiya [Clinical Dermatology and Venerology]. 2020; 19 (2): 154–61. DOI: https://doi.org/10.17116/klinderma202019021154 (in Russian)

3. Matyskina N.V., Taranushenko T.E. Early congenital syphilis: solved and unresolved issues of diagnosis. Rossiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2019; 64 (2): 75–80. DOI: https://doi.org/10.21508/1027-4065-2019-64-2-75-80 (in Russian)

4. Rotanov S.V., Frigo N.V., Dolya O.V., Sapozhnikova N.A., Mardanly S.G., Kitaeva N.V. Registration of the results of screening and verifying immunochemical studies for syphilis. Klinicheskaya laboratornaya diagnostika [Clinical Laboratory Diagnostics]. 2020; 65 (8): 521–8. DOI: https://doi.org/10.18821/0869-2084-2020-65-8-521-528 (in Russian)

5. Potekaev N.N., Negasheva E.S., Frigo N.V., Novozhilova O.L., Zhukova O.V., Kitaeva N.V. Prevention of syphilis: types and strategic directions. Profilakticheskaya meditsina [Preventive Medicine]. 2019; 22 (2): 38–44. DOI: https://doi.org/10.17116/profmed20192202138 (in Russian)

6. Federal clinical guidelines for the management of patients with syphilis. In: Russian Society of Dermatovenerologists and Cosmetologists. Moscow, 2015: 45 p. (in Russian)

7. Enkhbat E., Korenromp E.L., Badrakh J. Adult female syphilis prevalence, congenital syphilis case incidence and adverse birth outcomes, Mongolia 2000–2016: estimates using the Spectrum STI tool. Int Dis Model. 2018; 3: 13–22. DOI: https://doi.org/10.1016/j.idm.2018.03.003

8. Wijesooriya N.S., Rochat R.W., Kamb M.L., et al. Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. Lancet Glob Health. 2016; 4 (8): e525–33. DOI: https://doi.org/10.1016/S2214-109X(16)30135-8

9. Korenromp E.L., Mahiané S.G., Nagelkerke N., et al. Syphilis prevalence trends in adult women in 132 countries – estimations using the Spectrum Sexually Transmitted Infections model. Sci Rep. 2018; 8 (1): 11503. DOI: https://doi.org/10.1038/s41598-018-29805-9

10. WHO guidelines for the treatment of Treponema pallidum (syphilis). World Health Organization [Electronic resource]. 2016. URL: http://www.who.int/reproductivehealth/publications/rtis/syphilis-treatment-guidelines/en/ (date of access November 12, 2020)

CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425
Вскрытие
Medicine today

Уважаемые коллеги! Представляем оргкомитет 17-го Национального конгресса терапевтов (с международным участием) , который состоится 12-14 октября в МВЦ "Крокус Экспо" (павильон 3, Зал 20, г. Москва). · Президент Российского научного медицинского общества терапевтов,...

IV Съезд онкологов Московской области 7 октября 2022 года Активное развитие онкологической службы позволяет эффективно решать проблемы, возникающие на всех уровнях оказания помощи пациентам с онкозаболеваниями. Одним из успешных примеров такого взаимодействия является IV...

II Всероссийская конференция с международным участием "Воспаление глаза" 12 ноября 2022 года, Москва Воспалительные заболевания глаза - широко распространенная и многогранная проблема, с которой может столкнуться в своей практике любой специалист. Найти оптимальные алгоритмы...


Journals of «GEOTAR-Media»