Improvement of diagnostic measures in newborn babies born to mothers with syphilitic infection at the maternity hospital stage
Aim of the study. To consider the possibility of creating a modern model of organization of medical care for children born to women with syphilitic infection detected during this pregnancy or within five years before its onset, with a differentiated approach and choice of diagnostic tactics at the maternity hospital stage.
Material and methods. The paper analyzes the data of a comprehensive examination of 397 newborns included in the studies indicating the fact of birth by a woman with a documented history of syphilitic infection, and who were under observation from birth to 1 month of life for the period 2003–2020.
Results. A comparison of the results of serological reactions confirms the diagnostic significance of a combination of non-treponemal (RMP) and treponemal (RPGA and IgM and IgG ELISA), but the highest diagnostic significance is noted with a combination of direct and indirect diagnostic methods, which determines the need to introduce new diagnostic models aimed at optimizing laboratory studies of children born to women with syphilis during a real pregnancy or for three years before a real pregnancy.
Discussion. The model of medical care involves the improvement of a set of measures by optimizing laboratory diagnostics at the maternity hospital stage.
Conclusion. The introduction of the proposed modern model of organization of medical care for children born to women with syphilitic infection will provide a new modern approach to the choice of diagnostic tactics at the perinatal center/maternity hospital stage.
Keywords:syphilis; newborn; congenital infection
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
Contribution. Research concept and design – Matyskina N.V., Taranushenko T.E.; collection and processing of the material, statistical data processing – Matyskina N.V.; writing a text – Matyskina N.V., Taranushenko T.E.; editing – Matyskina N.V., Taranushenko T.E., Vinnik Yu.Yu.
For citation: Matyskina N.V., Taranushenko T.E., Vinnik Yu.Yu. Improvement of diagnostic measures in newborn babies born to mothers with syphilitic infection at the maternity hospital stage. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2022; 10 (2): 14–20. DOI: https://doi.org/10.33029/2308-2402-2022-10-2-14-20 (in Russian)
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