The choice of enteral nutrition for full-term newborns in conditions of delayed lactogenesis from the standpoint of understanding the functional features of the gastrointestinal tract in the neonatal period

Abstract

Aim. The assessment of the nutrition and functional status of the gastrointestinal tract of newborns with an adapted formula based on goat’s milk (NANNY classic) as a supplementary feed.

Material and methods. The prospective cohort study was conducted between August 2021 and April 2022 at the Department of Neonatology, Institute of Neonatology and Pediatrics, Moscow, Russia. 64 healthy full-term newborns were included. Group 1 (n=32) fed as supplementary feeding by an adapted formula based on goat’s milk “NANNY classic”. Group 2 (n=32) was breastfed only. All newborns underwent anthropometry, food diary keeping, and laboratory examinations of feces and fecal carbohydrates during the time of hospitalization (5–6 days of life) and in 1 month of life.

Results Newborns of group 2 showed significantly higher carbohydrate content in feces compared to group 1 (0.9±0.5 vs 0.5±0.2%, p<0.05) on 5–6 days of life, and at one month (0.9±0.4 vs 0.5±0.3%, p<0.05). We found a statistically significant difference between the groups at the end of the first month in the number of children who received lactase – group 1 (n=14) and group 2 (n=21) (43.8 vs 65.6%, р<0.05). The difference between the number of samples with Bifidobacteria on days 5–6 of life was 19 (59.4%) vs 24 (75%) (p<0.05) in 1 month of life. In group 2 on days 5–6 of life, 17 (53.1%) vs 22 (68.8%) (p<0.05). We performed additional analysis of Bifidobacteria 1010–12 in feces at the age of 1 month of life. The number of samples with a high concentration in group 1 was 22 (68.8%) vs 14 (43.7%) in group 2 (p<0.05). At the age of 1 month of life, the number of biological fecal samples with a high concentration of Lactobacillus 1010–12 in group 1 was significantly higher 7 (21.9%) vs 3 (9.4%) in group 2 (p<0.05). The number of stool samples with an average concentration of Lactobacillus 107–9 in group 1 was 9 (28.1%) vs 4 (12.5%) in group 2 (p<0.05).

Anthropometric, biochemical blood parameters characterizing protein, carbohydrate, fat, and electrolytes metabolism, indicators of red blood did not reveal significant statistical differences.

Conclusion. The use of an adapted formula based on goat’s milk “NANNIE classic” as supplementary food for newborns, provided that lactase deficiency is corrected in a timely manner, leads to adequate dynamics of growth of bifidobacteria and lactobacilli in biological stool samples, decrease in cry duration and prevalence of gastrointestinal dyspeptic disorders. The results obtained determine this formula as the product of choice for infants born by vaginal delivery, under conditions of delayed lactogenesis in the early neonatal period.

Keywords:term newborn; supplementary feeding; goat’s milk formula; lactase deficiency; Lacto- and Bifidobacteria; intestinal microflora; lactase

Funding. The study was funded by the Bibicall company.

Conflict of interest. The authors declare no conflict of interest.

For citation: Grosheva E.V., Zubkov V.V., Gorodnova E.A., Molkova E.A., Volostnykh D.A., Grebneva O.V., Dzhukkayeva M.M., Zorina P.S., Kazantseva I.A., Kuznetsova E.E., Shumakova O.V. The choice of enteral nutrition for full-term newborns in conditions of delayed lactogenesis from the standpoint of understanding the functional features of the gastrointestinal tract in the neonatal period. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2022; 10 (4): 17–27. DOI: https://doi.org/10.33029/2308-2402-2022-10-4-17-27 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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