Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

Abstract

The article presents the clinical observation of a premature infant with bronchopulmonary dysplasia who developed severe acute respiratory syncytial virus (RSV) bronchiolitis.

The different data were presented in the article. We demonstrated the epidemiology, etiology, diagnostics, and therapy of acute bronchiolitis. The passive immunization with palivizumab and its efficacy in preventing RSV lower respiratory tract infection showed. The number of it prescriptions in Moscow’s region have estimated in the article. Analysis of the therapy, clinical, laboratory and radiological findings of acute RSV bronchiolitis was analyzed in a comparison of modern medical literature.

Keywords:respiratory syncytial virus; acute bronchiolitis; bronchopulmonary dysplasia; immunoprophylaxis; palivizumab

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Ovsyannikov D.Yu., Tsverava A.G., Krsheminskaya I.V., Tsygankov A.E., Mikheeva A.A., Berezhanskiy P.V., Miroshnichenko V.P., Sigova Yu.A., Nikolishin A.N., Gorev V.V. Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2022; 10 (4): 63–74. DOI: https://doi.org/10.33029/2308-2402-2022-10-4-63-74 (in Russian)

REFERENCES

1. Ovsyannikov D.Yu., Krsheminskaya I.V., Ukraintsev S.E. Acute bronchiolitis. In: D.Y. Ovsyannikov (ed.). Neonatal Pulmonology: Monograph. Moscow, 2022: 46–65. (in Russian)

2. Sukhorukova D.N., Kuznetsova T.A. Experience in managing acute bronchitis in children in outpatient settings. Rossiyskiy pediatricheskiy zhurnal [Russian Journal of Pediatrics]. 2018; 21 (3): 139–44. DOI: http://dx.doi.org/10.18821/1560-9561-2018-21-3-139-144 (in Russian)

3. Ovsyannikov D.Y. Acute bronchiolitis in children. Voprosy prakticheskoy pediatrii [Problems of Practical Pediatrics]. 2010; 5 (2): 75–84. (in Russian)

4. Ovsyannikov D.Yu., Krsheminskaya I.V. Acute bronchiolitis. In: B.M. Blokhin (ed.). Pediatric Pulmonology: A national guide. Moscow: GEOTAR-Media, 2021: 358–73. DOI: https://doi.org/10.33029/9704-5857-0-2021-DEP-1-960 (in Russian)

5. Ovsyannikov D.Yu., Krsheminskaya I.V. Immunoprophylaxis of respiratory syncytial viral infection: why it is important from an epidemiological and clinical point of view. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2017; (2): 34–49. (in Russian)

6. Krsheminskaya I.V., Ovsyannikov D.Yu., Degtyarev D.N., Degtyareva E.A. Respiratory syncytial viral bronchiolitis in premature infants and predictors of its severe course. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2016; (2): 67–80. (in Russian)

7. Bokerya E.L., Degtyareva E.A., Kovalev I.A., Soldatova I.G. Respiratory syncytial viral infection in children with congenital heart defects: the relevance of the problem and recommendations for prevention. Rossiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2014; 59 (5): 101–8. (in Russian)

8. Ovsyannikov D.Yu., Zhestkova M.A. Outpatient management of children with bronchopulmonary dysplasia: what is important to know for a neonatologist and a pediatrician? Voprosy prakticheskoy pediatrii [Problems of Practical Pediatrics]. 2021; 16 (4): 115–24. DOI: https://doi.org/10.20953/1817-7646-2021-4-115-124 (in Russian)

9. Tatochenko V.K., Bakradze M.D. Pediatrician for every day – 2022. Fevers. Handbook of diagnosis and treatment. Moscow: FGAU «NMITs zdorov’ya detey» Minzdrava Rossii, 2022: 91–9. (in Russian)

10. Malakhov A.B., Andzhel’ A.E., Berezhansky P.V., Elagina V.I., Gorev V.V., Gorbunov A.V., Sedova A.Yu. Interleukin profile in children with acute bronchiolitis (raw data). Doctor.Ru. 2021; 20 (10): 12–7. (in Russ). DOI: https://doi.org/10.31550/1727-2378-2021-20-10-12-17 (in Russian)

11. Miller E.K., Bugna J., Libster R., et al. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics. 2012; 129 (1): e60–7.

12. Ovsyannikov D.Yu., Nazarova T.I., Krsheminskaya I.V., et al. Severe rhinovirus bronchiolitis in premature infant with bronchopulmonary dysplasia. Pediatriya. Zhurnal imeni G.N. Speranskogo [Pediatrics Journal named after G.N. Speransky]. 2017; 96 (4): 207–11. (in Russian)

13. Suleiman-Martos N., Caballero-Vázquez A., Gómez-Urquiza J.L., et al. Prevalence and risk actors of respiratory syncytial virus in children under 5 years of age in the WHO European Region: a systematic review and meta-analysis. J Pers Med. 2021; 11: 416. DOI: https://doi.org/10.3390/jpm11050416

14. Usenko D.V., Tkhakushinova N.Kh., Shaturina T.T., et al. Acute respiratory infections and flu during the COVID-19 pandemic. What to expect in 2021–2022? RMZh. Meditsinskoe obozrenie [RMJ. Medical Review]. 2021; 5 (11): 721–7. DOI: https://doi.org/10.32364/2587-6821-2021-5-11-721-727 (in Russian)

15. Weekly flu bulletin [Electronic resource]. URL: https://www.influenza.spb.ru/system/epidemic_situation/laboratory_ diagnostics/ (date of access July 06, 2022) (in Russian)

16. Acute bronchiolitis. Clinical recommendations. Moscow, 2021: 22 p. URL: https://diseases.medelement.com/disease (date of access July 10, 2022) (in Russian)

17. American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management and prevention of bronchiolitis. Pediatrics. 2014; 134: 1474–502.

18. Di Fiore J.M., Martin R.J., Gauda E.B. Apnea of prematurity – perfect storm. Respir Physiol Neurobiol. 2013; 189 (2): 213–22. DOI: https://doi.org/10.1016/j.resp.2013.05.026

19. Petryaykina E.S., Boytsova E.V., Ovsyannikov D.Yu., Gitinov Sh.A., Petryaykina E.E. Modern ideas about obliterating bronchiolitis in children. Pediatriya. Zhurnal imeni G.N. Speranskogo [Pediatrics Journal named after G.N. Speransky]. 2020; 99 (2): 255–62. (in Russian)

20. Belyashova M.A., Ovsyannikov D.Yu., Koltunov I.E. Respiratory diseases in children with Down syndrome. Pediatriya. Zhurnal imeni G.N. Speranskogo [Pediatrics Journal named after G.N. Speransky]. 2017; 96 (2): 58–64. (in Russian)

21. Shi T., Vennard S., Mahdy S., Nair H. Risk factors for RSV associated acute lower respiratory infection poor outcome and mortality in young children: a systematic review and meta-analysis. J Infect Dis. 2022; 226: S10–6. DOI: https://doi.org/10.1093/infdis/jiaa751

22. Baraldi E., Lanari M., Manzoni P., et al. Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants. Ital J Pediatr. 2014; 40: 65. DOI: https://doi.org/10.1186/1824-7288-40-65

23. Friedman J.N., Rieder M.J., Walton J.M.; Canadian Paediatric Society, Acute Care Committee, Drug Therapy and Hazardous Substances Committee. Bronchiolitis: recommendations for diagnosis, monitoring and management of children one to 24 months of age. Paediatr Child Health. 2014; 19: 485–98.

24. National Institute for Health and Care Excellence. Bronchiolitis: diagnosis and management of bronchiolitis in children. URL: http://www.NiceOrgUk/Guidance/Ng9 (date of access July 06, 2022)

25. Tapiainen T., Aittoniemi J., Immonen J. et al. Finnish guidelines for the treatment of laryngitis, wheezing bronchitis and bronchiolitis in children. Acta Paediatr. 2016; 105: 44–9. DOI: https://doi.org/10.1111/apa.13162

26. O’Brien S., Borland M.L., Cotterell E., et al. Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network, Australasia. Australasian bronchiolitis guideline. J Paediatr Child Health. 2019; 55 (1): 42–53. DOI: https://doi.org/10.1111/jpc.14104

27. Marcos-Morales A., García-Salido A., Leoz-Gordillo I., et al. Respiratory and pharmacological management in severe acute bronchiolitis: were clinical guidelines not written for critical care? Arch Pediatr. 2021; 28 (2): 150–5. DOI: https://doi.org/10.1016/j.arcped.2020.11.007

28. Mecklin M., Heikkilä P., Korppi M. The change in management of bronchiolitis in the intensive care unit between 2000 and 2015. Eur J Pediatr. 2018; 177 (7): 1131–7. DOI: https://doi.org/10.1007/s00431-018-3156-4

29. Pierce H.C., Mansbach J.M., Fisher E.S., et al. Variability of intensive care management for children with bronchiolitis. Hosp Pediatr. 2015; 5: 175–84. DOI: https://doi.org/10.1542/hpeds.2014-0125

30. Instructions for the medical use of the drug Synagis. LP-005242-101218. (in Russian)

31. Zhuravleva M.V., Gagarina Yu.V., Marin T.V., Asmolova G.A., Sigova Yu.A., Krsheminskaya I.V., Ovsyannikov D.Yu. Expected effect of palivizumab on the reduction of infant mortality and hospitalizations rates due to respiratory syncytial virus infection. Voprosy prakticheskoy pediatrii [Problems of Practical Pediatrics]. 2022; 17 (2): 55–64. DOI: https://doi.org/10.20953/1817-7646-2022-2-55-64 (in Russian)

32. A systematic review of European clinical practice guidelines for respiratory syncytial virus prophylaxis. J Infect Dis. 2022; 226 (suppl 1): S110–6. DOI: https://doi.org/10.1093/infdis/jiac059

33. The IMpact-RSV Study Group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics. 1998; 102 (3 pt 1): 531–7.

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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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