Caffeine citrate in neonatology: history, pharmacodynamics and pharmacokinetics, clinical effects, dosage regimens: a review

Abstract

Caffeine citrate is the most common prescribed drug for apnea of prematurity. This review briefly highlights the issues of the history of the use of caffeine citrate, provides up-to-date information on the short-term and long-term effects of caffeine citrate, its effectiveness, safety and dosage regimens in premature infants. We analyzed relevant studies published over the last 50 years. Literature searches were conducted using PubMed, Cochrane Library, EMBASE, Web of Science, Chinese Biomedical Literature databases. This review makes it possible to highlight the perspective of further studies.

Keywords:caffeine citrate; apnea of prematurity; preterm infants

Conflict of interest. The authors declare no conflict of interest.

Funding. The study had no sponsor support.

For citation: Lenyushkina A.A., Andreyev A.V., Sharafutdinova D.R., Krogh-Jensen O.A. Caffeine citrate in neonatology: history, pharmacodynamics and pharmacokinetics, clinical effects, dosage regimens: a review. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2023; 11 (1): 76–82. DOI: https://doi.org/10.33029/2308-2402-2023-11-1-76-82

(in Russian)

Received 20.02.2023. Accepted 16.03.2023.

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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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