Неонатология № 4 (42), 2023


News, Opinions, Training

Since October 2022 the "Neonatology: News, Opinions, Training" journal has been included into Scopus, an international database.

The journal is published in collaboration with All-Russian Public Organization for Assisting Development of Neonatology «Russian Society of Neonatologists»

The journal is intended to become a guide for medical practitioners being a part of the continuing medical education of physicians in Russia.

Topic number
4 . 2023
For the Congress “Anesthesia and Reanimation in Obstetrics and Neonatology”

Towards the XVI All-Russian Educational Congress “Anesthesia and Reanimation in Obstetrics and Neonatology”


To the 80th anniversary of Professor Vladislav A. Romanenko


Albert G. Antonov (28.10.1938–01.12.2017)

Original researches

Hypophosphatemia in premature infants: screening and clinical aspects


Current area of research is the study of a risk factors, formation of mechanisms, and clinical features of hypophosphatemia in premature infants in order to develop new approaches to screening, prevention and the early correction.

Aim. To study the clinical aspects of hypophosphatemia in very premature infants.

Material and methods. The study included premature infants of gestational age 24/0–31/6 weeks (n=84). The subjects were divided into an observation group (n=49; 58.3%) and a comparison group (n=35; 41.7%). The main criterion for inclusion in the observation group was hypophosphatemia – serum phosphorus concentration ≤4.5 mg/dL (≤1.45 mmol/L). The comparison group included premature infants with serum phosphorus concentrations higher than the specified values. Laboratory monitoring of phosphorus-calcium metabolism indicators in dynamics was carried out at the age of 6–8 and 9–12 weeks of life. When the enteral nutrition was performed, the intake of calcium (mg/kg/day), phosphorus (mg/kg/day) and vitamin D (IU/kg/day) calculated on days 14, 28 and 42 of life. Statistical processing of the material was performed using non-parametric criteria. Differences were considered statistically significant at p<0.05.

Results. In the group of premature infants with hypophosphatemia, a long duration of parenteral nutrition was observed – 44.0 (36.5–52.5) days (p=0.010), low enteral supplementation of minerals and the need for prolonged respiratory support – 11.0 (6.8–26.3) days (p=0.049). Necrotizing enterocolitis was significantly more often diagnosed in the observation group (26.5% compared to 5.7%, p=0.015). The severe condition of the children in the observation group required a longer stay in the Perinatal Center – 67.0 (57.0–74.0) days [in the comparison group – 58.0 (45.3–69.5) days, p=0.023]. During X-ray examination at 6–8 weeks of life, signs of damage to the bone system characteristic of metabolic bone disease were observed only in children of the observation group – in 30.0% of those examined by X-ray methods.

Conclusion. The most significant clinical aspects identified in premature infants with hypophosphatemia are long-term parenteral nutrition and low enteral supplementation of minerals, due to decreased tolerance to enteral load, the nature and severity of the pathology, among which necrotizing enterocolitis and early neonatal sepsis play pivotal role. Radiological signs of metabolic bone damage at the age of 6–8 weeks were observed in 30.0% of premature infants with hypophosphatemia.


Health status of children born from mothers with breast cancer during pregnancy: a review of the literature


The article provides a review of the scientific literature devoted to the study of the health characteristics of newborns from mothers with breast cancer during pregnancy. Modern approaches to the treatment and prolongation of pregnancy in this cohort of women analyzed. The impact of maternal cancer and chemotherapy during pregnancy on the child’s health is discussed.

Clinical case

Clinical case of Kasabach–Merritt syndrome in the practice of a neonatologist


Kasabach–Merritt syndrome (KMS) is a rare disease characterized by the presence of a vascular tumor with progressive invasive growth, development of thrombocytopenia and consumptive coagulopathy. In the neonatal period, the disease can characterized by the skin manifestations and hide under the guise of an intrauterine infection. Depending on the location in different organs and systems, multiple organ failure develops. The article discusses modern approaches of the management of patients with KMS, and also given the description in a clinical case of the newborn with KMS. Manifestations of this syndrome were noted from birth. The presence of concomitant pathology can cause difficulties in making a right way of diseases.

Case report of valproic acid-associated hyperammonemia in a newborn


Transient hyperammonemia of the neonate (THAN) is an abnormal condition characterized by increase of the ammonia blood levels (above 110 μmol/L in term infants and above 150 μmol/L in preterm infants) and do not associated with inborn errors of metabolism. THAN is usually caused by perinatal complications and occurs mostly in premature babies and babies with another disorders such as a perinatal asphyxia, a portosystemic shunting, the liver and renal failure and infections with urea-metabolizing organisms. Besides that, hyperammonemia can be caused of valproic acid as a seizures’ treatment in infants. Nevertheless, the etiology hyperammonemia can be a reason of the irreversible brain cells damage that defines the importance of an early detection and medical emergency.

Lawyer column

Clinical recommendations as a source of mandatory requirements: is it possible to punish non-compliance?


The article is devoted to the debatable issue of mandatory implementation of clinical recommendations and their legal status. The article explains whether clinical recommendations form mandatory requirements, the implementation of which carried out within the framework of state quality control and safety of medical activities.


Assessment of a woman’s mental state in the postpartum period


The article is devoted to the debatable issue of mandatory implementation of clinical recommendations and their legal status. The article explains whether clinical recommendations form mandatory requirements, the implementation of which carried out within the framework of state quality control and safety of medical activities.

Clinical practice guidlines

Apnea of prematurity (draft of clinical guidelines)


The article presents draft of consensus guideline for clinical management of newborns with apnea of prematurity: definition, etiology, pathogenesis, classification, clinical features, diagnosis and evidence-based treatment, follow up, management algorithm and healthcare quality criteria.

Congenital cytomegalovirus infection (guideline)


The article presents guideline for the management of newborns with congenital cytomegalovirus infection approved by associations and Ministry of Health of the Russian Federation: definitions, etiology, pathogenesis, classification, clinical picture, diagnosis and treatment of this pathology based on evidence-based medicine, follow up, algorithm of doctor’s management and health care quality criteria.

News of Cochrane database

News of Cochrane database (# 4, 2023)

Neonatology news

Neonatology news (# 4, 2023)


All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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