Production of reactive oxygen species by peripheral blood phagocytes in preterm infants in the early neonatal period

• Zhukova A.S.
• Irina V. Nikitina
• Vanko L.V.
• Matveeva N.K.
• Lyubov V. Krechetova
• Oleg V. Ionov
• Leila A. Timofeeva
• Dmitriy N. Degtyarev

Abstract

The aim. Of this study was to investigate the features of reactive oxygen species (ROS) production by phagocytic ceLLs in peripheraL bLood of newborn infants in the earLy neonataL period depending on their gestationaL age and cLinicaL condition.

Material and methods. Prospective study was performed on bLood sampLes from 65 newborns: 48 preterm infants with respiratory diseases and 17 heaLthy fuLL-term newborns. The intensity of zymosan-induced ROS production was determined by chemiLuminescence method. LuminoL- and isoLuminoL-dependent chemiluminescence was identified in the first hours of Life, the third day of Life and at the end of the early neonataL period (seventh day of Life) of preterm newborns.

Results. The intensity of ROS production by peripheraL bLood phagocytes of newborns is significantly affected by gestational age. Both extra- and intraceLLuLar ROS production was decreased at birth in newborns with diseases of the respiratory system characterized by the deveLopment of systemic infLammation. It was shown that the differences in the functional activity of ROS-producing cells in preterm infants disappear by the third day of Life.

Keywords:phagocytes, reactive oxygen species, newborn, neonatal infection, respiratory disorders, survey

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)