Biomarkers of perinatal lesions of the central nervous system

• Zadvornov A.A.
• Golomidov A.V.
• Grigoriev E.V.

AbstractPerinatal brain injury is one of the most urgent problems of neonatology. One of the most promising tools for the detection of the central nervous system (CNS) lesions is biomarkers of brain injury. Despite the large number of studies on biomarkers in newborns, this diagnostic tool is not entered in clinical practice. This article summarizes the literature on the nature of biomarkers, measuring their levels in biological fluids in infants with intact and damaged CNS, as well as reviewed the data on the predictive value of biomarkers. For the introduction biomarkers into clinical practice, first of all, we must address their clinical positioning, define reference values, interpreting their standard deviations.

Keywords:biomarkers of brain damage; hypoxic-ischemic encephalopathy

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