Features of nursing newborns from mothers with a new coronavirus infection COVID-19 in the conditions of a regional perinatal center

Abstract

Aim of the study – comprehensive assessment of factors harming the newborns of mothers in COVID-19. The definition of perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2.

Material and methods. A retrospective study was conducted in the Department of Neonatal Intensive Care (3rd level) of the Regional Clinical Hospital #2. The ward is a separate division of the Perinatal Center (Ministry of Health of the Krasnodar Territory). Ninety-two newborns were included in the study. The gestational age was between the 22nd and 41st weeks of gestation (average 35 weeks). Mothers have confirmed new coronavirus infection or in the group of risk.

Results and discussion. Clinical experience received in the health management of newborns has shown that there were different criteria of disadaptation in the early neonatal period. Children have had a high incidence of respiratory disorders and can require respiratory therapy, early hemodynamic failure, and a tendency to hemorrhagic complications. A significant proportion of them had the signs of infectious diseases specific to the perinatal period. Babies from mothers with severe COVID-19 had at high risk of severe perinatal asphyxia. Adverse neonatal outcomes in newborns were associated with severe prematurity or the presence of co-morbidities.

Conclusion. The differential diagnostics of the new coronavirus infection in a newborn without the specific clinical manifestations and the violence of adaptation in the early neonatal period will require the development plan of the routing and assistance for the third-level institutions.

Keywords:novel coronavirus infection (COVID-19); mothers with COVID-19; fetus; newborns; transplacental transmission of SARS-CoV-2

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Model G.Yu., Tokovaya I.A., Eremina O.V., Lapita A.R. Features of nursing newborns from mothers with a new coronavirus infection COVID-19 in the conditions of a regional perinatal center. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2022; 10 (3): 8–15. DOI: https://doi.org/10.33029/2308-2402-2022-10-3-8-15 (in Russian)

REFERENCES

1.Jafari M., Pormohammad A., Sheikh Neshin S.A., Ghorbani S., Bose D., Alimohammadi S., et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: a systematic review and meta-analysis. Rev Med Virol. 2021; 31 (5): 1–16.

2. Chamseddine R.S., Wahbeh F., Chervenak F., Salomon L.J., Ahmed B., Rafii A. Pregnancy and neonatal outcomes in SARS-CoV-2 infection: a systematic review. J Pregnancy. 2020; 7. DOI: https://doi.org/10.1155/2020/4592450

3. Suy A., Garcia-Ruiz I., Carbonell M., Garcia-Manau P., Rodo C., Maiz N., et al. Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19). BMC Pregnancy Childb. 2021; 21 (1): 4–9.

4. Vivanti A.J., Vauloup-Fellous C., Prevot S., Zupan V., Suffee C., Do Cao J., et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020; 11 (1): 3572. DOI: https://doi.org/10.1038/s41467-020-17436-6

5. Adamyan L.V., Artymuk L.V., Bezhenar’ V.F., et al. Organization of medical care for pregnant women, women in childbirth, puerperas and newborns with a new coronavirus infection COVID-19. In: Methodological recommendations Ministry of Health of Russia. Version 4 dated 05/07/2021]. 131 p. (in Russian)

6. Molloy E.J., Bearer C.F. COVID-19 in children and altered inflammatory responses. Pediatr Res. 2020; 88 (3): 340–1. DOI: https://doi.org/10.1038/s41390-020-0881-y

7. Zimmermann P., Curtis N. Coronavirus infections in children including COVID-19, an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020; 39 (5): 355–68. DOI: https://doi.org/10.1097/INF.0000000000002660

8. Adamyan L.V., Artymuk N.V., Baev O.R., et al. Organization of medical care for pregnant women, women in childbirth, puerperas and newborns with a new coronavirus infection COVID-19. In: Methodological recommendations. Moscow; 2020: 30–41. (in Russian)

9. Avdeev S.N., Adamyan L.V., Alekseeva E.I., Bagnenko S.F., et al. Prevention, diagnosis and treatment of a new coronavirus infection 2019-nCoV. In: Temporary guidelines of the Ministry of Health of Russia. Version 7 from 06/03/2020: 165 p. (in Russian)

10. Aleksandrovich Yu.S., Alekseyeva E.I., Bakradze M.D., Baranov A.A., et al. Peculiarities of clinical manifestations and treatment of a disease caused by a new coronavirus infection (COVID-19) in children. In: Methodological recommendations of the Ministry of Health of Russia. Version 2 dated 07/03/2020: 73 p. (in Russian)

11. Di Rentso D.K., Makatsariya A.D., Tsibizova V.I., Kapanna F., Razero B., Komlichenko E.V., et al. On the principles of operation of the perinatal hospital in the context of the coronavirus pandemic. Vestnik RAMN [Bulletin of the Russian Academy of Medical Sciences]. 2020; 75 (1): 83–92. (in Russian)

12. Khripun A.I., Antsiferov M.B., Belevsky A.S., Bulanov A.Yu., et al. Clinical protocol for the treatment of children with a new coronavirus infection (COVID-19) who are hospitalized in medical organizations of the state healthcare system of Moscow. In: Clinical Protocol. Moscow; 2021: 6–51. (in Russian)

13. Zhu H., Wang L., Fang C., Peng S., Zhang L., Chang G., et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020; 9 (1): 51–60. DOI: https://doi.org/10.21037/tp.2020.02.06

14. Hong H., Wang Y., Chung H.-T., Chen C.-J. Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children. Pediatr Neonatol. 2020; 61 (2): 131–2.

15. Sankaran D., Nakra N., Cheema R., Blumberg D., Lakshminrusimha S. Perinatal SARS-CoV-2 infection and neonatal COVID-19: a 2021 update. Neoreviews. 2021; 22 (5): 284–95. DOI: https://doi.org/10.1542/neo.22-5-e1001

16. Pawar R., et al. Neonatal multisystem inflammatory syndrome (MIS-N) associated with prenatal maternal SARS-CoV-2: a case series. Children. 2021; 8 (4): 572.

17.Recommendations of Rospotrebnadzor dated April 9, 2020 No. 02/6475-2020-32 on the use and handling of protective clothing and personal protective equipment when working in contact with COVID-19 patients (suspected of disease) or when working with the biological material of such patients. URL: https://www.rospotrebnadzor.ru/region/korono_virus/rek_ros.php (in Russian)

18.Recommendations of Rospotrebnadzor dated April 9, 2020 No. 02/6509-2020-32 to prevent the spread of a new coronavirus infection (COVID-19) in medical organizations that provide inpatient care. URL: https://www.rospotrebnadzor.ru/region/korono_virus/rek_ros.php (in Russian)

19.Recommendations of Rospotrebnadzor on prevention of new coronavirus infection (COVID-19) among employees. URL: https://www.rospotrebnadzor.ru/region/korono_virus/rek_ros.php (in Russian)

20.Order of the Ministry of health of the Russian Federation No. 198n from 19.03.2020 “On the temporary procedure for organizing the work of medical organizations in order to implement measures to prevent and reduce the risks of spreading a new COVID-19 coronavirus infection” (as amended on March 27, 2020 N 246n) https://rg.ru/2020/03/20/minzdravprikaz198-site-dok.html (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

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