Features of brain bioelectric activity in congenital central hypoventilation syndrome (clinical case)

• Aleksandrovich Yuriy S.
• Pshenisnov Konstantin V.
• Nikita Yu. Kipyatkov
• Ekaterina Yu. Pavlovskaya
• Nataliya A. Belyaeva

Abstract

Congenital central hypoventilation syndrome is a rare genetic disorder characterized by a pronounced depression of the respiratory drive. It is pronounced during wakefulness and sleep, but more at night and requires long-term respiratory support. The only way to detect the syndrome is polysomnography, followed by molecular genetic analysis of the patient’s genome. For primary diagnosis at the earliest possible stage, daily monitoring of the EEG with subsequent visual assessment of the data obtained and the spectral power analysis is justified. Changes in the EEG during the slow phase of sleep in the form of an alternating curve with the duration of the inter-breath intervals ranging from 13 to 30 seconds (in individual episodes up to 80 seconds) are an indirect sign of central hypoventilation syndrome and indicate the need for in-depth genetic investigation by studying the expansion of trinucleotide repeats.

Keywords:congenital central hypoventilation syndrome; newborn; electroencephalogram; bioelectric activity of the brain

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