A newborn with severe asphyxia and rhabdomyolysis. Experience of treatment using various methods of renal replacement therapy and hemosorption

Abstract

This article presents the successful experience of using various methods of efferent therapy: renal replacement therapy (peritoneal dialysis, continuous veno-venous hemofiltration), hemoperfusion in a newborn child with rhabdomyolysis and severe asphyxia at birth.

Keywords:renal replacement therapy; dialysis; hemosorption; hemoperfusion; hemofiltration; peritoneal dialysis; rhabdomyolysis; newborn; hypoxia; asphyxia

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Tukabaev G.P., Makulova A.I., Toporkova A.O., Philippov A.S., Ignatieva E.A., Kamenev M.M., Kozheurova Z.A., Mashtac N.A., Fomenko S.A., Makarova L.M., Kholodnova N.V., Abaseeva T.Yu., Vavilova A.I., Gorev V.V., Afukov I.I. A newborn with severe asphyxia and rhabdomyolysis. Experience of treatment using various methods of renal replacement therapy and hemosorption. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2025; 13 (1): 52–9. DOI: https://doi.org/10.33029/2308-2402-2025-13-1-52-59 (in Russian)

References

1. Stanley M., Chippa V., Aeddula N.R., Quintanilla Rodriguez B.S., Adigun R. Rhabdomyolysis [Updated 2023 Apr 16]. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing, 2024 Jan.

2. Petejova N., Martinek A. Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review. Crit Care. 2014; 18: 224.

3. Kuok C.I., Chan W.K.Y. Acute kidney injury in pediatric non-traumatic rhabdomyolysis. Pediatr Nephrol. 2021; 36 (10): 3251–7. DOI: https://doi.org/10.1007/s00467-021-05057-0

4. Zhu D.C., Li W.Y., Zhang J.W., Tong J.S., Xie W.Y., Qin X.L., et al. Rhabdomyolysis-associated acute kidney injury: clinical characteristics and intensive care unit transfer analysis. Intern Med J. 2022; 52 (7): 1251–7. DOI: https://doi.org/10.1111/imj.15308

5. Yang J., Zhou J., Wang X., Wang S., Tang Y., Yang L. Risk factors for severe acute kidney injury among patients with rhabdomyolysis. BMC Nephrol. 2020; 21 (1): 498. DOI: https://doi.org/10.1186/s12882-020-02104-0

6. Agharokh L., Zaniletti I., Yu A.G., Lee B.C., Hall M., Williams D.J., et al. Trends in pediatric rhabdomyolysis and associated renal failure: a 10-year population-based study. Hosp Pediatr. 2022; 12 (8): 718–25. DOI: https://doi.org/10.1542/hpeds.2021-006484

7. Kolovou G., Cokkinos P., Bilianou H., Kolovou V., Katsiki N., Mavrogeni S. Non-traumatic and non-drug-induced rhabdomyolysis. Arch Med Sci Atheroscler Dis. 2019; 4: e252–63. DOI: https://doi.org/10.5114/amsad.2019.90152

8. Borisov A.G., Chernov S.A., Potekhin N.P., Romanov V.P. Nontraumatic rhabdomyolysis as the reason of acute renal injury. Nefrologiya [Nephrology]. 2019; 23 (suppl 1): 44. DOI: https://doi.org/10.36485/1561-6274-2019-23-5-44-54 (in Russian)

9. Subashri M., Sujit S., Thirumalvalavan K., Poongodi A., Srinivasaprasad N.D., Edwin Fernando M. Rhabdomyolysis-associated acute kidney injury. Indian J Nephrol. 2023; 33 (2): 114–8. DOI: https://doi.org/10.4103/ijn.ijn_247_21 Epub 2023 Feb 20.

10. Masolitin S.V., Protsenko D.N., Tyurin I.N., Mamontova O.A., Magomedov M.A., Kim T.G., et al. Prevalence, structure, frequency of complications and outcomes of treatment of rhabdomyolysis in acute exogenous intoxication in a multidisciplinary hospital. Toksikologecheskiy vestnik [Toxicological Bulletin]. 2022; 30 (6): 370–6. DOI: https://doi.org/10.47470/0869-7922-2022-30-6-370-376 (in Russian)

11. Krivochina E.A., Surkov M.V. Rhabdomyolysis and acute kidney damage in severe combined trauma. Universum: meditsina i farmakologiya [Universum: Medicine and Pharmacology]. 2024; 2 (107): 27–9. (in Russian)

12. Basile C. Rhabdomyolysis: have you considered food poisoning from quails? G Ital Nefrol. 2020; 37 (2): 2020-vol2.

13. Diaz J.H. Global incidence of rhabdomyolysis after cooked seafood consumption (Haff disease). Clin Toxicol (Phila). 2015; 53 (5): 421–6. DOI: https://doi.org/10.3109/15563650.2015.1016165 Epub 2015 Mar 19.

14. Murakami A., Lau R.L., Wallerstein R., Zagustin T., Kuwada G., Purohit P.J. Acute rhabdomyolysis in a child with multiple suspicious gene variants. Case Rep Pediatr. 2022; 2022: 2099827. DOI: https://doi.org/10.1155/2022/2099827

15. Scott Schwoerer J., Cooper G., van Calcar S. Rhabdomyolysis in a neonate due to very long chain acyl CoA dehydrogenase deficiency. Mol Genet Metab Rep. 2015; 3: 39–41. DOI: https://doi.org/10.1016/j.ymgmr.2015.03.003

16. Silva G. Jr, Pinto G., Fraga Y., Daher E. Acute kidney injury due to rhabdomyolysis: a review of pathophysiology, causes, and cases reported in the literature, 2011–2021. Rev Colomb Nefrol. 2023; 10. DOI: https://doi.org/10.22265/acnef.10.3.619

17. Kasik J.W., Leuschen M.P., Bolam D.L., Nelson R.M. Rhabdomyolysis and myoglobinemia in neonates. Pediatrics. 1985; 76 (2): 255–8.

18. Nakaoka S., Kawasaki Y., Inomata S., Makimoto M., Yoshida T. Caffeine toxicity in a preterm neonate. Pediatr Neonatol. 2017; 58 (4): 380–1.

19. Hui W.F., Hon K.L., Lun K.S., Leung K.K.Y., Cheung W.L., Leung A.K.C. Successful treatment of rhabdomyolysis-associated acute kidney injury with haemoadsorption and continuous renal replacement therapy. Case Rep Pediatr. 2021; 2021: 2148024. DOI: https://doi.org/10.1155/2021/2148024

20. Li X., Bai M., Yu Y., Ma F., Zhao L., Li Y., et al. Earlier continuous renal replacement therapy is associated with reduced mortality in rhabdomyolysis patients. Ren Fail. 2022; 44 (1): 1743–53. DOI: https://doi.org/10.1080/0886022X.2022.2132170 PMID: 36259466; PMCID: PMC9586620.

21. Titova A.D., Terenin M.A., Dovgalevich I.I., Motuz S.I., Mishchenko A.M. Review of the AAGT intensive care committee clinical consensus on the management of patients with rhabdomyolysis. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency Cardiology and Cardiovascular Risks], 2022; 6 (1): 1563–71. (in Russian)

22. Forni L., Aucella F., Bottari G., Büttner S., Cantaluppi V., Fries D., et al. Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force. BMC Nephrol. 2024; 25 (1): 247. DOI: https://doi.org/10.1186/s12882-024-03679-8

23. Rauch S., Borgato A., Gruber E., Leggieri C., Bock M., Seraglio P.M.E. Case report: prevention of rhabdomyolysis-associated acute kidney injury by extracorporeal blood purification with Cytosorb®. Front Pediatr. 2022; 9: 801807. DOI: https://doi.org/10.3389/fped.2021.801807

24. Padiyar S., Deokar A., Birajdar S., Walawalkar A., Doshi H. Cytosorb for management of acute kidney injury due to rhabdomyolysis in a child. Indian Pediatr. 2019; 56 (11): 974–6.

25. Saito K., Nakagawa R., Narumi S., Ohashi H., Ishiguro A., Kabe K. A small-for-gestational-age infant with MIRAGE syndrome who developed heat stroke and rhabdomyolysis due to severe temperature instability. Neonatology. 2023; 120 (3): 390–4. DOI: https://doi.org/10.1159/000529762

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425
geotar-digit

Journals of «GEOTAR-Media»